反应条件
1: 2.97 g / Et3N / tetrahydrofuran / 5 h / 0 °C
2: 650 mg / PPh3, Pd(OAc)2, NaHCO3 / dimethylformamide / 16 h / 110 °C
3: 444 mg / DIBAL-H / CH2Cl2; hexane / 4 h / -78 - 20 °C
View Scheme
参考文献
Henke, Brad R.; Aquino, Christopher J.; Birkemo, Larry S.; Croom, Dallas K.; Dougherty Jr., Robert W.; Ervin, Gregory N.; Grizzle, Mary K.; Hirst, Gavin C.; James, Michael K.; Johnson, Michael F.; Queen, Kennedy L.; Sherrill, Ronald G.; Sugg, Elizabeth E.; Suh, Edward M.; Szewczyk, Jerzy W.; Unwalla, Rayomand J.; Yingling, Jeff; Willson, Timothy M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 17 p. 2706 - 2725