4-哌啶-1-基-1-丁醇合成路线 （共 12 条）
反应条件
1,4-dioxane; copper oxide-chromium oxide
T=240°C; P=147102 - 220652 Torr; Hydrogenation;
参考文献
Sauer; Adkins
Journal of the American Chemical Society, 1938 , vol. 60, p. 402,406
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
0.166667 h; Reflux;
2: With water in tetrahydrofuran; diethyl ether
参考文献
AVENTIS PHARMA S.A.
Patent: US2009/197866 A1, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
1 h; Ambient temperature;
参考文献
Kafka, Stanislav; Ferles, Miloslav
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 78 - 85
反应条件
1: 84 percent / potassium carbonate / butan-2-one / 7 h / Heating
2: 47 percent / Heating; reaction in nitrogen atmosphere
3: 61 percent / HCl 15percent / H2O; acetone / 0.25 h / Heating
4: 94 percent / NaOH 3M, H2O2 (30percent) / H2O; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kafka, Stanislav; Ferles, Miloslav
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 78 - 85
反应条件
1: 47 percent / Heating; reaction in nitrogen atmosphere
2: 61 percent / HCl 15percent / H2O; acetone / 0.25 h / Heating
3: 94 percent / NaOH 3M, H2O2 (30percent) / H2O; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kafka, Stanislav; Ferles, Miloslav
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 78 - 85
反应条件
1: 61 percent / HCl 15percent / H2O; acetone / 0.25 h / Heating
2: 94 percent / NaOH 3M, H2O2 (30percent) / H2O; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kafka, Stanislav; Ferles, Miloslav
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 78 - 85
反应条件
potassium carbonate; sodium iodide in ethanol
12 h; Reflux;
参考文献
Lemaitre, Stephane; Lepailleur, Alban; Bureau, Ronan; Butt-Gueulle, Sabrina; Lelong-Boulouard, Veronique; Duchatelle, Pascal; Boulouard, Michel; Dumuis, Aline; Daveu, Cyril; Lezoualc'h, Frank; Pfeiffer, Bruno; Dauphin, Francois; Rault, Sylvain
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2607 - 2622
反应条件
T=150°C; Erwaermen des Reaktionsgemisches mit Lithiumalanat in Aether.;
参考文献
Lunsford et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 1225,1227
参考文献
Wasserman
Sbornik Rabot Rizsk. med. Inst.Chem.Abstr., 1956 , # 5 p. 23,35
Sbornik Rabot Rizsk. med. Inst.Chem.Abstr., 1961 , p. 5487
Full Text Show Details
Vejdelek; Trcka
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 1860,1863
参考文献
BASF
Patent: DE877457 , 1952 ;
