(3,5-二甲氧基苯基)乙酸合成路线 （共 46 条）
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane T=0°C; 3 h;
参考文献
UNIVERSITY HEALTH NETWORK; LAUFER, Radoslaw; PAULS, Heinz W.; FEHER, Miklos; NG, Grace; LIU, Yong; EDWARDS, Louise G.; PATEL, Narendra Kumar B.; PAN, Guohua; MAK, Tak W.
Patent: WO2011/123937 A1, 2011 ;
Location in patent: Page/Page column 78 ;
WO 2011/123937 A1
反应条件
sodium hydroxide; dihydrogen peroxide in ethanol Heating;
参考文献
Kozlowski, Marisa C.; Dugan, Elizabeth C.; DiVirgilio, Evan S.; Maksimenka, Katja; Bringmann, Gerhard
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 583 - 594
反应条件
potassium hydroxide 0.5 h; Heating;
参考文献
Liang, Qiren; Zhang, Jiyong; Quan, Weiguo; Sun, Yongquan; She, Xuegong; Pan, Xinfu
Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2694 - 2697
反应条件
formic acid; potassium iodide; [RhCl(η2:η2-cycloocta-1,5-diene)]2 T=60°C; P=760 Torr; 24 h;
参考文献
Saeed, Aamer; Rama, Nasim H.; Arfan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 3 p. 519 - 522
反应条件
1: With morpholine; toluene-4-sulfonic acid; sulfur T=120 - 130°C; Willgerodt-Kindler reaction; 6 h; 2: With tetrabutylammomium bromide; sodium hydroxide in water T=100 - 110°C; 6 h;
参考文献
Sun, Hong-Yi; Xiao, Chun-Fen; Cai, Yu-Chen; Chen, Yu; Wei, Wen; Liu, Xian-Ke; Lv, Ze-Liang; Zou, Yong
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 11 p. 1492 - 1496
反应条件
1: 86 percent / PBr3 / CH2Cl2 / 1 h / 20 °C 2: 83 percent / dimethylformamide / 1 h 3: 90 percent / conc. HCl / 2.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 4-5 p. 583 - 594
反应条件
1: 93 percent / BH3*THF / tetrahydrofuran / 12 h 2: 70 percent / methanesulfonyl chloride; triethylamine 3: 1-methyl-pyrrolidin-2-one / 5 h 4: HCl / H2O / 5 h / 70 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 19 p. 5942 - 5943
反应条件
1: 1-methyl-pyrrolidin-2-one / 5 h 2: HCl / H2O / 5 h / 70 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 19 p. 5942 - 5943
反应条件
1: 1,3-dimethoxy-5-methyl-benzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane Inert atmosphere; regioselective reaction;
参考文献
Fleming, Patricia; Oshea, Donal F.
Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1698 - 1701
反应条件
1: 83 percent / dimethylformamide / 1 h 2: 90 percent / conc. HCl / 2.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 4-5 p. 583 - 594
