(2-苯基-1H-吲哚-3-基)乙酸合成路线 （共 12 条）
反应条件
silver tetrafluoroborate; palladium diacetate; trifluoroacetic acid in N,N-dimethyl-formamide
T=90°C; 0.333333 h; Inert atmosphereMicrowave irradiationSealed tube;
参考文献
Preciado, Sara; Mendive-Tapia, Lorena; Albericio, Fernando; Lavilla, Rodolfo
Journal of Organic Chemistry, 2013 , vol. 78, # 16 p. 8129 - 8135
反应条件
sodium hydroxide
3 h; Heating;
参考文献
Kozikowski, A. P.; Ma, D.; Brewer, James; Sun, S.; Costa, E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2908 - 2920
反应条件
ethanol; sodium cyanide
T=200°C;
参考文献
Winthrop Chem. Co.
Patent: US2315661 , 1940 ;
Full Text Show Details
I. G. Farbenind.
Patent: DE722809 , 1939 ;
DRP/DRBP Org.Chem.
反应条件
potassium cyanide; ethanol
T=150°C;
参考文献
Winthrop Chem. Co.
Patent: US2222344 , 1939 ;
Full Text Show Details
I.G. Farbenind.
Patent: DE679283 , 1937 ;
DRP/DRBP Org.Chem.
反应条件
1: 73 percent / H2SO4 / 24 h / Heating
2: 3 N aq. NaOH / 3 h / Heating
View Scheme
参考文献
Kozikowski, A. P.; Ma, D.; Brewer, James; Sun, S.; Costa, E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2908 - 2920
反应条件
1: 73 percent / H2SO4 / 24 h / Heating
2: 3 N aq. NaOH / 3 h / Heating
View Scheme
参考文献
Kozikowski, A. P.; Ma, D.; Brewer, James; Sun, S.; Costa, E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2908 - 2920
反应条件
1: dimethyl amine / acetic acid / 3 h / 0 °C / pH 12
2: toluene / 12 h
3: water; acetonitrile / 5 h / |Reflux
4: hydrogenchloride; water / 1,4-dioxane / 2 h / |Reflux
View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
1: potassium hydroxide / methanol / 4 h / |Reflux
2: dimethyl amine / acetic acid / 3 h / 0 °C / pH 12
3: toluene / 12 h
4: water; acetonitrile / 5 h / |Reflux
5: hydrogenchloride; water / 1,4-dioxane / 2 h / |Reflux
View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
1: toluene / 12 h
2: water; acetonitrile / 5 h / |Reflux
3: hydrogenchloride; water / 1,4-dioxane / 2 h / |Reflux
View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
反应条件
1: water; acetonitrile / 5 h / |Reflux
2: hydrogenchloride; water / 1,4-dioxane / 2 h / |Reflux
View Scheme
参考文献
Arisawa, Mitsuhiro; Kasaya, Yayoi; Obata, Tohru; Sasaki, Takuma; Nakamura, Tomonori; Araki, Takuya; Yamamoto, Koujirou; Sasaki, Akito; Yamano, Akihito; Ito, Mika; Abe, Hiroshi; Ito, Yoshihiro; Shuto, Satoshi
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8152 - 8163
