4-甲氧基-3-丁烯-2-酮合成路线 （共 41 条）
反应条件
(i) tBuLi, (ii) CuBr, Me2S, (iii) /BRN= 1741053/; Multistep reaction;
参考文献
Marino,J.P.; Browne,L.J.
Journal of Organic Chemistry, 1976 , vol. 41, # 22 p. 3629 - 3632
反应条件
1: With sodium ethanolate in ethanol
3 h; Reflux;
2: With hydrogenchloride in dichloromethane; water
参考文献
Kallman, Neil J.; Liu, Chin; Yates, Matthew H.; Linder, Ryan J.; Ruble, J. Craig; Kogut, Eugene F.; Patterson, Lawrence E.; Laird, Dana L. T.; Hansen, Marvin M.
Organic Process Research and Development, 2014 , vol. 18, # 4 p. 501 - 510
反应条件
1: With sodium methylate in ethanol
2 h; Heating / reflux;
2: With sodium hydroxide; water
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/129962 A1, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/129962 A1
反应条件
1: Cl2 / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Heasley, Victor L.; Elliott, Stephen L.; Erdman, Paul E.; Figueroa, Daphne E.; Krosley, Kevin W.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 3 p. 393 - 399
反应条件
chlorine
Ambient temperature;
参考文献
Heasley, Victor L.; Elliott, Stephen L.; Erdman, Paul E.; Figueroa, Daphne E.; Krosley, Kevin W.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 3 p. 393 - 399
反应条件
1: Br2 / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Heasley, Victor L.; Elliott, Stephen L.; Erdman, Paul E.; Figueroa, Daphne E.; Krosley, Kevin W.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 3 p. 393 - 399
反应条件
bromine
Ambient temperature;
参考文献
Heasley, Victor L.; Elliott, Stephen L.; Erdman, Paul E.; Figueroa, Daphne E.; Krosley, Kevin W.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 3 p. 393 - 399
反应条件
(i) tBuLi, (ii) CuBr, Me2S, (iii) /BRN= 1741053/; Multistep reaction;
参考文献
Marino,J.P.; Browne,L.J.
Journal of Organic Chemistry, 1976 , vol. 41, # 22 p. 3629 - 3632
反应条件
(i) tBuLi, (ii) CuBr, Me2S, (iii) /BRN= 1741053/; Multistep reaction;
参考文献
Marino,J.P.; Browne,L.J.
Journal of Organic Chemistry, 1976 , vol. 41, # 22 p. 3629 - 3632
反应条件
1: With titanium tetrachloride in dichloromethane
T=-78 - 20°C; 14 h; Inert atmosphere;
2: With hydrogenchloride; water in dichloromethane
Inert atmosphere; regioselective reaction;
参考文献
Mross, Gerson; Ladzik, Simone; Reinke, Helmut; Spannenberg, Anke; Fischer, Christine; Langer, Peter
Synthesis, 2009 , # 13 art. no. T15708SS, p. 2236 - 2248
