2-氨基-4-甲基噻吩-3-羧酸甲酯合成路线 （共 4 条）
反应条件
sodium hydroxide 1.) n-PrOH, 24 h, reflux,; Yield given. Multistep reaction;
参考文献
Sugiyama; Sakamoto; Tabata; Endo; Ito; Kobayashi; Fukumi
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2122 - 2131
反应条件
in diethyl ether; ethanol
参考文献
DOWELANCO
Patent: EP452002 A2, 1991 ;
反应条件
piperidine; sulfur in ethanol
T=80°C; Gewald Aminoheterocycles Synthesis;
参考文献
Park, Chun-Ho; Lee, Chulho; Yang, Jee Sun; Joe, Bo-Young; Chun, Kwangwoo; Kim, Hyuntae; Kim, Hye Yun; Kang, Jong Soon; Lee, Jangik I.; Kim, Myung-Hwa; Han, Gyoonhee
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2655 - 2660
反应条件
Mg(ClO4)2*2H20
T=140°C; 3 h;
参考文献
Puterova, Zita; Bobula, Tomas; Vegh, Daniel
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 201 - 207
