2-氨基-3-腈基-4,5-二甲基噻吩合成路线 （共 12 条）
反应条件
octasulfur; bovine serum albumin in N,N-dimethyl-formamide T=50°C; Gewald Aminoheterocycles Synthesis; 4 h;
参考文献
Zhao, Dan-Dan; Li, Li; Xu, Fan; Wu, Qi; Lin, Xian-Fu
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 29 - 35
反应条件
sulfur in ethanol T=0 - 50°C; 4 h;
参考文献
Erickson, Shawn David; Gillespie, Paul; Guertin, Kevin Richard
Patent: US2004/209943 A1, 2004 ;
Location in patent: Page/Page column 5 ;
反应条件
1H-imidazole; sulfur in N,N-dimethyl-formamide T=60°C; Gewald reaction; 12 h; Inert atmosphere;
参考文献
Huang, Xian-Gui; Liu, Jia; Ren, Jiangmeng; Wang, Tao; Chen, Weidong; Zeng, Bu-Bing
Tetrahedron, 2011 , vol. 67, # 34 p. 6202 - 6205
反应条件
morpholine; sulfur in N,N-dimethyl-formamide T=20 - 120°C; Gewald reaction; 0.166667 h;
参考文献
Seek, Pierre; Thomae, David; Kirsch, Gilbert
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 3 p. 853 - 857
反应条件
1: 85 percent / sodium hydroxide / dimethylformamide / 1 h 2: 1 M aq. potassium hydroxide / 2 h / Heating View Scheme
参考文献
Sukumaran, P.; Rajasekharan, K. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 642 - 646
反应条件
sulfuric acid; water T=65 - 70°C; 2 h;
参考文献
Bakavoli, Mehdi; Bagherzadeh, Ghodsieh; Vaseghifar, Maryam; Shiri, Ali; Pordeli, Parvaneh
Journal of Chemical Research, 2009 , # 11 p. 653 - 655
反应条件
pyridine in 1,4-dioxane 0.5 h;
参考文献
Gewald, K.; Jeschke, T.; Gruner, M.
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 229 - 236
反应条件
hydrogenchloride in 1,4-dioxane 12 h; Ambient temperature;
参考文献
Shishoo, C. J.; Devani, M. B.; Bhadti, V. S; Jain, K. S.; Ananthan, S.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 119 - 126
反应条件
hydrogenchloride in 1,4-dioxane
12 h; Ambient temperature;
参考文献
Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Anathan, S.; Ullas, G. V.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4611 - 4612
参考文献
Rahman, Khandker M. M.; Shaifullah Chowdhury; Bhuiyan; Hossain; Uddin
Pakistan Journal of Scientific and Industrial Research, 2003 , vol. 46, # 2 p. 95 - 98
