2-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩合成路线

108-94-1环己酮+109-77-3丙二腈→4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩

参考文献

Zhao, Dan-Dan; Li, Li; Xu, Fan; Wu, Qi; Lin, Xian-Fu
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 29 - 35

4354-73-82-环己基亚己基丙二腈→4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩

参考文献

Feroci, Marta; Chiarotto, Isabella; Rossi, Leucio; Inesi, Achille
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2740 - 2746

108-94-1环己酮→4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩

参考文献

Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo
Synthetic Communications, 2004 , vol. 34, # 20 p. 3801 - 3806

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩+79-04-9一氯代乙酰氯→58125-40-92-氯-N-(3-氰基-4,5,6,7-四氢-1-苯并噻吩-2-基)乙酰胺

参考文献

SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2005/44008 A2, 2005 ;
Location in patent: Page/Page column 113 ;

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩→4815-28-52-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺

参考文献

Offermann; Eger; Roth
Archiv der Pharmazie, 1981 , vol. 314, # 2 p. 168 - 175

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩+75-36-5乙酰氯→20036-97-9

参考文献

Shehata; El-Subbagh; Abdelal; El-Sherbeny; Al-Obaid
Medicinal Chemistry Research, 1996 , vol. 6, # 3 p. 148 - 163

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩+64-19-7醋酸→20036-97-9

参考文献

Harikrishnan, Lalgudi S.; Srivastava, Neelam; Kayser, Lauren E.; Nirschl, David S.; K, Kumaragurubaran; Roy, Amrita; Gupta, Anuradha; Karmakar, Sukhen; Karatt, Tajudheen; Mathur, Arvind; Burford, Neil T.; Chen, Jing; Kong, Yan; Cvijic, Maryellen; Cooper, Christopher B.; Poss, Michael A.; Trainor, George L.; Wong, Tai W.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2287 - 2290

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩+108-24-7乙酸酐→20036-97-9

参考文献

Said, Ahmed; Youssef, Ahmed
Journal of Chemical Research, 2009 , # 4 p. 214 - 217

108-31-6马来酸酐+4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩→299953-51-8

参考文献

Shi, Mengxiao; Stauffer, Barbara; Bhat, Ramesh; Billiard, Julia; Ponce-de-Leon, Helga; Seestaller-Wehr, Laura; Fukayama, Shoichi; Mangine, Annamarie; Moran, Robert; Krishnamurthy, Girija; Bodine, Peter; Gopalsamy, Ariamala
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6337 - 6339

4651-91-62-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩+98-88-4苯甲酰氯→23903-48-2

参考文献

BASF Aktiengesellschaft
Patent: US5422335 A1, 1995 ;