3Α-羟基-7-氧代-5Β-胆烷酸 合成路线 （共 33 条）
反应条件
1: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 2: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 3: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 4: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
3749-87-9 甲基(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-二乙酰氧基-12-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酸酯
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反应条件
反应条件
1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / |Large scale 2: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 3: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
反应条件
1.1: hydrogenchloride / 1 h / |Reflux; |Large scale 2.1: 4-(N,N-dimethlyamino)pyridine / toluene / 20 °C / |Large scale 2.2: 19 h / 20 °C / |Large scale 3.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / |Large scale 4.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 5.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
反应条件
1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 2: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
反应条件
potassium hydroxide; water 1 h; Reflux;
参考文献
Kakiyama, Genta; Muto, Akina; Shimada, Miki; Mano, Nariyasu; Goto, Junichi; Hofmann, Alan F.; Iida, Takashi
反应条件
ethanol; platinum Hydrogenation;
参考文献
Iwasaki
反应条件
chromium(VI) oxide; acetic acid
参考文献
Iwasaki
参考文献
Fieser; Rajagopalan
参考文献
Fieser; Rajagopalan
参考文献
Iwasaki
