3Α-羟基-7-氧代-5Β-胆烷酸合成路线 （共 33 条）
反应条件
Sodium bromate; sulfuric acid; water; sodium bromide in dichloromethane; butan-1-ol T=0 - 55°C; Large scale;
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
Patent: WO2014/20024 A1, 2014 ;
Location in patent: Page/Page column 5; 9; 10 ;
反应条件
ethylenediaminetetraacetic acid; Acinetobacter calcoaceticus lwoffii 7α-hydroxysteroid dehydrogenase; sodium 2-oxopropanoate; nicotinamide adenine dinucleotide; 2-hydroxyethanethiol; lactate dehydrogenase in aq. phosphate buffer T=22°C; pH=8.5; Enzymatic reaction;
参考文献
Giovannini, Pier Paolo; Grandini, Alessandro; Perrone, Daniela; Pedrini, Paola; Fantin, Giancarlo; Fogagnolo, Marco
Steroids, 2008 , vol. 73, # 14 p. 1385 - 1390
反应条件
sodium hydroxide in ethanol; water T=90°C; 3 h;
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 12 p. 2059 - 2063
反应条件
air; Xanthomonas maltophilia CBS 827.97 in sodium hydroxide T=30°C; epimerisation; pH=8; 4 h;
参考文献
Medici, Alessandro; Pedrini, Paola; Bianchini, Ercolina; Fantin, Giancarlo; Guerrini, Alessandra; Natalini, Benedetto; Pellicciari, Roberto
Steroids, 2002 , vol. 67, # 1 p. 51 - 56
→
2955-27-34-[(5S,7S,8S,10S,13R,17R)-3,7,12-三羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酸
反应条件
Saccharothrix longispora VKM Ac-1265 in methanol; aq. phosphate buffer pH=7; Microbiological reaction;
参考文献
Kollerov; Monti; Deshcherevskaya; Lobastova; Ferrandi; Larovere; Gulevskaya; Riva; Donova
Steroids, 2013 , vol. 78, # 3 p. 370 - 378
反应条件
1: 100 percent / 20 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 2: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C 3: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 4: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 5: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 6: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 7: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
Patent: WO2014/20024 A1, 2014 ;
反应条件
1: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 2: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 3: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 12 p. 2059 - 2063
反应条件
1: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 2: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 12 p. 2059 - 2063
反应条件
1: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C 2: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 3: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 4: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 5: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 6: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 12 p. 2059 - 2063
反应条件
1: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 2: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 3: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 4: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 5: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme
参考文献
Sugai, Takeshi; Takizawa, Masahiro; Bakke, Mikio; Ohtsuka, Yoshikazu; Ohta, Hiromichi
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 12 p. 2059 - 2063
