(S)-2-氨基-4-苯基丁酸乙酯合成路线 （共 15 条）
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Vaidya, Bhalchandra K.; Kuwar, Suyog S.; Golegaonkar, Sandeep B.; Nene, Sanjay N.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 3-4 p. 184 - 191
反应条件
1.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C 2.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 3.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
tert.-butylnitrite; 3-chloro-benzenecarboperoxoic acid; isopentyl nitrite 1.) chloroform, 2.) 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 23, # 17 p. 1875 - 1876
反应条件
in ethylene glycol dimethyl ether
T=50°C; 60 h;
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
1.1: 100 percent / Et3N / ethanol / 12 h / 20 °C
2.1: H2; HCl / Pd-C / tetrahydrofuran / 40 h / 40 °C / 7757.22 Torr
2.2: acetic acid / toluene / 24 h / Heating
View Scheme
参考文献
Yu, Luo-Ting; Huang, Ji-Ling; Chang, Ching-Yao; Yang, Teng-Kuei
Molecules, 2006 , vol. 11, # 8 p. 641 - 648
