盐酸-4-哌啶酮-3-羧酸乙酯合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; water P=2280 Torr; 24 h; Ambient temperature;
参考文献
Ngo, Anh Ngoc; El Kassimi, Khadija; Amara, Zacharias; Drege, Emmanuelle; Joseph, Delphine
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3296 - 3300
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
Zheng, Guangrong; Smith, Andrew M.; Huang, Xiaoqin; Subramanian, Karunai L.; Siripurapu, Kiran B.; Deaciuc, Agripina; Zhan, Chang-Guo; Dwoskin, Linda P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 4 p. 1693 - 1703
反应条件
1: 96 percent / NaCO3, NaCl / CHCl3; H2O / 12 h / Heating 2: 59 percent / NaOH, NH2OH*HCl / H2O / 1 h / 0 °C 3: 86 percent / H2 / 10percent Pt/C / ethanol / Ambient temperature View Scheme
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
反应条件
1: NaOH; MTBE / H2O 2: H2 / Ra-Ni / ethanol 3: Et3N / tetrahydrofuran 4: DBU / tetrahydrofuran 5: 98 percent / NaOH / H2O; methanol / 15 h / 20 °C View Scheme
参考文献
Knapp; Zhao
Organic letters, 2000 , vol. 2, # 25 p. 4037 - 4040
反应条件
1: 96 percent / NaCO3, NaCl / CHCl3; H2O / 12 h / Heating 2: 81 percent / hydrazine hydrate / ethanol; H2O / 70 deg C, 3 h; r.t., 12 h View Scheme
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
反应条件
N-ethyl-N,N-diisopropylamine
参考文献
Eli Lilly and Company
Patent: US6664271 B1, 2003 ;
Location in patent: Page column 10 ;
反应条件
1: NaOH; MTBE / H2O 2: H2 / Ra-Ni / ethanol 3: Et3N / tetrahydrofuran 4: DBU / tetrahydrofuran View Scheme
参考文献
Organic letters, , vol. 2, # 25 p. 4037 - 4040
反应条件
in chloroform; sulfuric acid
参考文献
Warner-Lambert Company
Patent: US3946008 A1, 1976 ;
