2-苯基吡啶-4-羧酸甲酯合成路线 （共 12 条）
反应条件
hydrogen; acetic acid; platinum(IV) oxide T=20°C; P=3750.38 Torr; 2.5 h;
参考文献
AstraZeneca AB
Patent: US2010/261755 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in methanol
T=100°C; 0.166667 h; microwave irradiation;
参考文献
AstraZeneca AB
Patent: US2010/261755 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
1: 4-pyridinecarboxylic acid methyl ester With trifluoroacetic acid in dichloromethane; water
0.25 h;
2: 3,4,5-trimethoxyphenylboronic acid With iron sulphate heptahydrate; dipotassium peroxodisulfate in dichloromethane; water
T=20°C; 5 h;
3: With sodium hydroxide in dichloromethane; water
T=20°C;
参考文献
Komeyama, Kimihiro; Nagao, Yuya; Abe, Manabu; Takaki, Ken
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 2 p. 301 - 313
反应条件
sulfuric acid
T=85°C; 12 h;
参考文献
Li, Yanfang; Liu, Yang; Zhou, Ming
Dalton Transactions, 2012 , vol. 41, # 9 p. 2582 - 2591
反应条件
1: With methanol in tetrahydrofuran
T=-78 - 20°C; Inert atmosphere;
2: With trifluoroacetic anhydride in tetrahydrofuran
T=20°C; 0.333333 h; regioselective reaction;
参考文献
Andersson, Hans; Sainte-Luce Banchelin, Thomas; Das, Sajal; Olsson, Roger; Almqvist, Fredrik
Chemical Communications, 2010 , vol. 46, # 19 p. 3384 - 3386
反应条件
ammonia in ethanol; dichloromethane
T=20°C; 16 h;
参考文献
Craig, Donald; Henry, Gavin D.
Tetrahedron Letters, 2005 , vol. 46, # 15 p. 2559 - 2562
反应条件
in methanol; hexane; benzene
T=0 - 20°C; 8 h;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 44 ;
US 20050054627 A1
反应条件
C60H48Cl2FeP4; Zn(C6H4-4-OMe)2 in tetrahydrofuran; toluene
T=115°C; Suzuki coupling; 16 h; Inert atmosphere;
参考文献
Bedford, Robin B.; Hall, Mark A.; Hodges, George R.; Huwe, Michael; Wilkinson, Mark C.
Chemical Communications, 2009 , # 42 p. 6430 - 6432
反应条件
1: 4-pyridinecarboxylic acid methyl ester With Iron (III) nitrate nonahydrate; dipotassium peroxodisulfate; trifluoroacetic acid in water
T=20°C; 0.166667 h; Schlenk technique;
2: 3,4,5-trimethoxyphenylboronic acid in water
T=50°C; 24 h; Schlenk technique; Overall yield = 80 percent;
参考文献
Deb, Arghya; Manna, Srimanta; Maji, Arun; Dutta, Uttam; Maiti, Debabrata
European Journal of Organic Chemistry, 2013 , # 24 p. 5251 - 5256
反应条件
1.1: O3 / CH2Cl2; methanol / 0 °C
1.2: 77 percent / PPh3 / CH2Cl2; methanol / 19 h / 0 - 20 °C
2.1: 82 percent / NH3 / ethanol; CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Craig, Donald; Henry, Gavin D.
Tetrahedron Letters, 2005 , vol. 46, # 15 p. 2559 - 2562
