(S)-2-(氟甲基)吡咯烷-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: With diethylamino-sulfur trifluoride in dichloromethane
T=0°C; 6 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1741703 A1, 2007 ;
Location in patent: Page/Page column 90 ;
EP 1741703 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Krause-Heuer, Anwen M.; Howell, Nicholas R.; Matesic, Lidia; Dhand, Geetanjali; Young, Emma L.; Burgess, Leena; Jiang, Cathy D.; Lengkeek, Nigel A.; Fookes, Christopher J. R.; Pham, Tien Q.; Sobrio, Franck; Greguric, Ivan; Fraser, Benjamin H.
MedChemComm, 2013 , vol. 4, # 2 p. 347 - 352
反应条件
1: triethylamine / dichloromethane
2: pyridine / dichloromethane
3: tetrabutyl ammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Krause-Heuer, Anwen M.; Howell, Nicholas R.; Matesic, Lidia; Dhand, Geetanjali; Young, Emma L.; Burgess, Leena; Jiang, Cathy D.; Lengkeek, Nigel A.; Fookes, Christopher J. R.; Pham, Tien Q.; Sobrio, Franck; Greguric, Ivan; Fraser, Benjamin H.
MedChemComm, 2013 , vol. 4, # 2 p. 347 - 352
反应条件
1: triethylamine / dichloromethane
2: pyridine / dichloromethane
3: tetrabutyl ammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Krause-Heuer, Anwen M.; Howell, Nicholas R.; Matesic, Lidia; Dhand, Geetanjali; Young, Emma L.; Burgess, Leena; Jiang, Cathy D.; Lengkeek, Nigel A.; Fookes, Christopher J. R.; Pham, Tien Q.; Sobrio, Franck; Greguric, Ivan; Fraser, Benjamin H.
MedChemComm, 2013 , vol. 4, # 2 p. 347 - 352
