4-羟基-3-碘-联苯-4-甲腈合成路线 （共 7 条）
反应条件
N-iodo-succinimide; sulfuric acid in acetic acid T=20°C; Inert atmosphere; stereoselective reaction;
参考文献
Pu, Yu-Ming; Grieme, Timothy; Gupta, Ashok; Plata, Daniel; Bhatia, Ashok V.; Cowart, Marlon; Ku, Yi-Yin
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 45 - 50
反应条件
sodium hydroxide; sodium iodide in methanol
参考文献
Abbott Laboratories
Patent: US6620839 B2, 2003 ;
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=20°C; Sonogashira reaction;
参考文献
Cowart, Marlon D.; Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy A.; Gupta, Ashok K.; Plata, Daniel J.; Faghih, Ramin; Gfesser, Gregory A.
Patent: US2004/54185 A1, 2004 ;
Location in patent: Page 10 ;
US 20040054185 A1
反应条件
1: 95 percent / Et3N; CuI; (Ph3P)2PdCl2 / dimethylformamide / 12 h / 65 °C 2: Et3N / CH2Cl2 / 2 h / -10 - 23 °C 3: 34 percent / Na2CO3 / acetonitrile / 48 h / 50 °C View Scheme
参考文献
Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide
Sonagashira-Stevens coupling; Heating;
参考文献
Cowart, Marlon; Faghih, Ramin; Curtis, Michael P.; Gfesser, Gregory A.; Bennani, Youssef L.; Black, Lawrence A.; Pan, Liping; Marsh, Kennan C.; Sullivan, James P.; Esbenshade, Timothy A.; Fox, Gerard B.; Hancock, Arthur A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 38 - 55
反应条件
copper monoiodide; triethylamine in N-methyl-acetamide; dichloromethane
参考文献
Cowart, Marlon D.; Bennani, Youssef L.; Faghih, Ramin; Black, Lawrence A.
Patent: US2002/183309 A1, 2002 ;
反应条件
1: 95 percent / Et3N; CuI; (Ph3P)2PdCl2 / dimethylformamide / 12 h / 65 °C
2: Et3N / CH2Cl2 / 2 h / -10 - 23 °C
View Scheme
参考文献
Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693
