(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈合成路线 （共 15 条）
反应条件
1: 86 percent / H2; Et3N / Pd/C / methanol / 20 °C 2: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C 3: K2CO3 / acetonitrile / 6 h / Heating 4: CuI; (i-Pr)2NH / PdCl2(PPh3)2 / acetonitrile / 20 °C View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
1: 85 percent / Bu3SnH; AIBN / toluene 2: 96 percent / HBr; AcOH 3: acetonitrile / 20 °C View Scheme
参考文献
Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693
反应条件
1: 96 percent / HBr; AcOH 2: acetonitrile / 20 °C View Scheme
参考文献
Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693
反应条件
1: 97 percent / SOCl2; HCl / CHCl3 2: 94 percent / Et3N / 0 °C 3: 85 percent / Bu3SnH; AIBN / toluene 4: 96 percent / HBr; AcOH 5: acetonitrile / 20 °C View Scheme
参考文献
Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693
反应条件
1.1: methanol; ethanol / |Inert atmosphere; |Large scale 2.1: potassium carbonate / acetonitrile / 48 h / 60 °C / |Inert atmosphere; |Large scale 2.2: 36 h / 25 - 60 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Pu, Yu-Ming; Grieme, Timothy; Gupta, Ashok; Plata, Daniel; Bhatia, Ashok V.; Cowart, Marlon; Ku, Yi-Yin
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 45 - 50
