(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈合成路线

460746-47-84-羟基-3-碘-联苯-4-甲腈+460747-73-33-丁炔-2-(R)-甲基吡咯烷→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon D.; Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy A.; Gupta, Ashok K.; Plata, Daniel J.; Faghih, Ramin; Gfesser, Gregory A.
Patent: US2004/54185 A1, 2004 ;
Location in patent: Page 10 ;
US 20040054185 A1

117607-13-3+460746-49-0→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon D.; Bennani, Youssef L.; Faghih, Ramin; Gfesser, Gregory A.; Black, Lawrence A.
Patent: US2002/169188 A1, 2002 ;

→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon D.; Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy A.; Gupta, Ashok K.; Plata, Daniel J.; Faghih, Ramin; Gfesser, Gregory A.
Patent: US2004/54185 A1, 2004 ;
Location in patent: Page 9-10 ;
US 20040054185 A1

→

参考文献

Pu, Yu-Ming; Grieme, Timothy; Gupta, Ashok; Plata, Daniel; Bhatia, Ashok V.; Cowart, Marlon; Ku, Yi-Yin
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 45 - 50

19812-93-2氰基联苯酚→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693

460746-47-84-羟基-3-碘-联苯-4-甲腈→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693

460746-48-94-[2-(2-羟基乙基)-1-苯并呋喃-5-基]苯甲腈→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Cowart, Marlon; Pratt, John K.; Stewart, Andrew O.; Bennani, Youssef L.; Esbenshade, Timothy A.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 689 - 693

69610-40-8N-Boc-L-脯氨醇→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589

132482-09-8→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589

157007-54-0(R)-1-Boc-2-甲基吡咯烷→460746-46-7(R)-4-(2-(2-(2-甲基吡咯烷-1-基)乙基)苯并呋喃-5-基)苯甲腈

参考文献

Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589