3-氨基-4-溴苯甲酸甲酯合成路线 （共 5 条）
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
反应条件
methanol; sodium dithionite in water 4 h; RefluxInert atmosphere;
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
Location in patent: Page/Page column 40; 41 ;
反应条件
N-bromosuccinmide in DCE T=20°C;
参考文献
Bartoli, Sandra; Cipollone, Amalia; Squarcia, Antonella; Madami, Andrea; Fattori, Daniela
Synthesis, 2009 , # 8 art. no. P12608SS, p. 1305 - 1308
反应条件
1: sulfuric acid / 4 h / 0 °C / |Reflux; |Inert atmosphere 2: methanol; sodium dithionite / water / 4 h / |Reflux; |Inert atmosphere View Scheme
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
反应条件
triethylamine; palladium diacetate; tris-(o-tolyl)phosphine in acetonitrile T=100°C; 20 h; sealed tube;
参考文献
Kasahara, Akira; Izumi, Taeko; Kikuchi, Tokio; Xiao-ping Lin
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1555 - 1556
