7-羟基-6-甲氧基-3,4-二氢异喹啉合成路线 （共 6 条）
反应条件
1: With trichlorophosphate in acetonitrile 4 h; Inert atmosphereReflux; 2: With ammonium hydroxide in water
参考文献
Biovali Laboratories International (Barbados) S.R.L.
Patent: US2010/87475 A1, 2010 ;
Location in patent: Page/Page column 34-35 ;
US 20100087475 A1
反应条件
hydrogen bromide T=95°C; 15 h;
参考文献
Pelletier, Jeffrey C.; Cava, Michael P.
Journal of Organic Chemistry, 1987 , vol. 52, # 4 p. 616 - 622
反应条件
toluene; trichlorophosphate
参考文献
Tomita; Watanabe
Yakugaku Zasshi, 1938 , vol. 58, p. 783,486;dtsch.Ref.S.223,226
Chem. Zentralbl., 1939 , vol. 110, # I p. 1978
参考文献
Pelletier, Jeffrey C.; Cava, Michael P.
Synthesis, 1987 , # 5 p. 474 - 477
反应条件
1: 1.) 40percent aq. HNO3, NaNO2, 2.) concd. NH3 / 1.) ethanol, 0 deg C, 30 min, 2.) methanol, reflux
2: 72 percent / 1 h / Heating
3: 96 percent / CH2Cl2; diethyl ether / 4 h
4: 77 percent / H2 / 5percent Pd/C / acetic acid / 1 h / 2327.2 Torr
5: B2H6 / tetrahydrofuran / 2 h / Heating
6: 39 percent / 5percent Pd/C / xylene / 3.5 h / Heating
View Scheme
参考文献
Pelletier; Cava
Tetrahedron Letters, 1985 , vol. 26, # 10 p. 1259 - 1260
反应条件
1: 2. Amberlite IRA 410 (Cl- form) / 1. DMSO, 24 h, room temp.
2: NaBH4, 2M HCl / methanol
View Scheme
参考文献
Jendrzejewski, Stefan
Phytochemistry (Elsevier), 1990 , vol. 29, # 1 p. 135 - 139
