2-氯-4-氨基苯甲酸甲酯合成路线 （共 11 条）
反应条件
1: With ethanol; tin(ll) chloride T=0 - 90°C; 2: With sodium hydroxide in water; ethyl acetate
参考文献
Frantz, Marie-Celine; Rodrigo, Jordi; Boudier, Laure; Durroux, Thierry; Mouillac, Bernard; Hibert, Marcel
Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1546 - 1562
反应条件
thionyl chloride T=0 - 20°C; 32 h;
参考文献
NOVARTIS AG; HEBACH, Christina; JOLY, Emilie; KALLEN, Joerg; TERNOIS, James Gilbert; TINTELNOT-BLOMLEY, Marina
Patent: WO2013/8162 A1, 2013 ;
Location in patent: Page/Page column 116 ;
反应条件
1: 4-amino-2-chloro-benzoic acid With lithium hydroxide in tetrahydrofuran T=20°C; 0.333333 h; 2: dimethyl sulfate in tetrahydrofuran 2 h; Heating / reflux;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1724268 A1, 2006 ;
Location in patent: Page/Page column 86 ;
反应条件
in methanol 18 h; Heating / reflux;
参考文献
Ferring B.V.
Patent: EP1449844 A1, 2004 ;
Location in patent: Page 23 ;
EP 1449844 A1
参考文献
Rubin et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 623
反应条件
1: pyridine 2: H2 / Pd/C View Scheme
参考文献
Kaur, Gurmeet; Narayanan, Ven L.; Risbood, Prabhakar A.; Hollingshead, Melinda G.; Stinson, Sherman F.; Varma, Ravi K.; Sausville, Edward A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1749 - 1761
反应条件
1: sulfuric acid / |Reflux 2: ethanol; tin(ll) chloride / 1.5 h / |Reflux View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68467 A1, 2013 ;
反应条件
2: OH- 3: SOCl2 View Scheme
参考文献
Albright, J. Donald; Reich, Marvin F.; Delos Santos, Efren G.; Dusza, John P.; Sum, Fuk-Wah; Venkatesan, Aranapakam M.; Coupet, Joseph; Chan, Peter S.; Ru, Xun; Mazandarani, Hossein; Bailey, Trina
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2442 - 2444
反应条件
T=250°C; 0.25 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 47, # 14 p. 2395 - 2398
参考文献
Albright, J. Donald; Reich, Marvin F.; Delos Santos, Efren G.; Dusza, John P.; Sum, Fuk-Wah; Venkatesan, Aranapakam M.; Coupet, Joseph; Chan, Peter S.; Ru, Xun; Mazandarani, Hossein; Bailey, Trina
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2442 - 2444
