1-甲基-4-硝基-1H-吡唑-3-羧酸合成路线 （共 6 条）
反应条件
potassium hydroxide in ethanol
参考文献
Regiec, Andrzej; Mastalarz, Henryk; Mastalarz, Agnieszka; Kochel, Andrzej
Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2624 - 2627
反应条件
sulfuric acid; nitric acid T=80°C; 3 h;
参考文献
Perevalov, V. P.; Andreeva, M. A.; Baryshnenkova, L. I.; Manaev, Yu. A.; Yamburg, G. S.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1326 - 1330
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1676 - 1679
反应条件
sulfuric acid; nitric acid T=55°C; nitrodeiodination; 6 h;
参考文献
Tret'yakov; Vasilevsky
Russian Chemical Bulletin, 1996 , vol. 45, # 11 p. 2581 - 2584
反应条件
in methanol T=20 - 40°C;
参考文献
Regiec, Andrzej; Mastalarz, Henryk; Mastalarz, Agnieszka; Kochel, Andrzej
Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2624 - 2627
反应条件
1: in methanol T=20 - 60°C; 2: in methanol T=40°C;
参考文献
Regiec, Andrzej; Mastalarz, Henryk; Mastalarz, Agnieszka; Kochel, Andrzej
Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2624 - 2627
反应条件
sulfuric acid
4 h; HeatingReflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/153589 A1, 2009 ;
Location in patent: Page/Page column 205-206 ;
WO 2009/153589 A1
