6-氯嘌呤 2’-脱氧核苷合成路线 （共 16 条）
反应条件
ammonia in methanol T=0°C; 9 h;
参考文献
Ikejiri, Masahiro; Saijo, Masayuki; Morikawa, Shigeru; Fukushi, Shuetsu; Mizutani, Tetsuya; Kurane, Ichiro; Maruyama, Tokumi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2470 - 2473
参考文献
SEGEV, David; MOYNIHAN, Martin
Patent: WO2006/10084 A2, 2006 ;
Location in patent: Page/Page column 81-83 ;
反应条件
Escherichia coli nucleoside 2'-deoxyribosyltransferase in water T=37°C; 4 h;
参考文献
Uddin, Md. Jashim; Schulte, Michael I.; Maddukuri, Leena; Harp, Joel; Marnett, Lawrence J.
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 11-12 p. 831 - 840
反应条件
sodium hydroxide in methanol; water 1.16667 h; Ambient temperature;
参考文献
Oivanen, Mikko; Loennberg, Harri; Zhou, Xiao-xiong; Chattopadhyaya, Jyoti
Tetrahedron, 1987 , vol. 43, # 6 p. 1133 - 1140
反应条件
1: t-BuONO; Et4NCl / CCl4; CH2Cl2 / 4.5 h / 0 - 50 °C 2: 76 percent / NH3 / methanol / 9 h / 0 °C View Scheme
参考文献
Ikejiri, Masahiro; Saijo, Masayuki; Morikawa, Shigeru; Fukushi, Shuetsu; Mizutani, Tetsuya; Kurane, Ichiro; Maruyama, Tokumi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2470 - 2473
反应条件
1: DMAP; pyridine / 4 h 2: t-BuONO; Et4NCl / CCl4; CH2Cl2 / 4.5 h / 0 - 50 °C 3: 76 percent / NH3 / methanol / 9 h / 0 °C View Scheme
参考文献
Ikejiri, Masahiro; Saijo, Masayuki; Morikawa, Shigeru; Fukushi, Shuetsu; Mizutani, Tetsuya; Kurane, Ichiro; Maruyama, Tokumi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2470 - 2473
反应条件
2: NaOH / H2O; methanol / 1.17 h / Ambient temperature View Scheme
参考文献
Oivanen, Mikko; Loennberg, Harri; Zhou, Xiao-xiong; Chattopadhyaya, Jyoti
Tetrahedron, 1987 , vol. 43, # 6 p. 1133 - 1140
反应条件
2: NaOH / H2O; methanol / 1.17 h / Ambient temperature View Scheme
参考文献
Oivanen, Mikko; Loennberg, Harri; Zhou, Xiao-xiong; Chattopadhyaya, Jyoti
Tetrahedron, 1987 , vol. 43, # 6 p. 1133 - 1140
反应条件
1: SOCl2 / dimethylformamide; CH2Cl2 2: Alumina, MeOH View Scheme
参考文献
Czernecki; Viswanadham; Valery
Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 2087 - 2091
反应条件
T=37°C; 16 h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli, ammonium acetate buffer pH 5.7;
参考文献
Votruba, Ivan; Holy, Antonin; Dvorakova, Hana; Guenter, Jaroslav; Hockova, Dana; et al.
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 10 p. 2303 - 2330
