3-(1H-吡唑-3-基)吡啶合成路线 （共 9 条）
反应条件
1: pyridine-3-aldehyde With sodium hydroxide; toluene-4-sulfonic acid hydrazide in ethanol T=20°C; 2.33333 h; 2: 1-vinyl-imidazole in ethanol; water T=50°C; 96 h;
参考文献
HUMAN BIOMOLECULAR RESEARCH INSTITUTE
Patent: WO2005/66162 A1, 2005 ;
Location in patent: Page/Page column 61-62 ;
WO 2005/066162 A1
反应条件
hydrazine hydrate in ethanol T=20°C; 3 h;
参考文献
Del Giudice, Maria Rosaria; Mustazza, Carlo; Borioni, Anna; Gatta, Franco; Tayebati, Khosrow; Amenta, Francesco; Tucci, Paolo; Pieretti, Stefano
Archiv der Pharmazie, 2003 , vol. 336, # 3 p. 143 - 154
反应条件
hydrogenchloride; ethanol T=20°C; 1 h;
参考文献
Gerard, Anne-Laure; Bouillon, Alexandre; Mahatsekake, Clement; Collot, Valerie; Rault, Sylvain
Tetrahedron Letters, 2006 , vol. 47, # 27 p. 4665 - 4669
反应条件
1: 94 percent / 2 h / Heating 2: 85 percent / hydrazine hydrate / ethanol / 0.67 h / 65 °C View Scheme
参考文献
Plate, Ralf; Plaum, Marc J. M.; De Boer, Thijs; Andrews, John S.; Rae, Duncan R.; Gibson, Sam
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 227 - 237
反应条件
hydrogenchloride; isopentyl nitrite beim Erwaermen der bereiteten Diazoniumsalz-Loesung mit Aethanol;
参考文献
Gough; King
Journal of the Chemical Society, 1933 , p. 350
反应条件
1: aqueous sodium acetate; N2H4+H2SO4 2: KMnO4 3: 310 °C View Scheme
参考文献
Gough; King
Journal of the Chemical Society, 1933 , p. 350
反应条件
1: KMnO4 2: 310 °C View Scheme
参考文献
Gough; King
Journal of the Chemical Society, 1933 , p. 350
反应条件
1: 3-(1H pyrazol-3-yl)-pyridine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
Del Giudice, Maria Rosaria; Mustazza, Carlo; Borioni, Anna; Gatta, Franco; Tayebati, Khosrow; Amenta, Francesco; Tucci, Paolo; Pieretti, Stefano
Archiv der Pharmazie, 2003 , vol. 336, # 3 p. 143 - 154
反应条件
potassium carbonate in methanol
6 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Plate, Ralf; Plaum, Marc J. M.; De Boer, Thijs; Andrews, John S.; Rae, Duncan R.; Gibson, Sam
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 227 - 237
