2-氯-N,N-二甲基丙胺 盐酸盐合成路线 (共 8 条)
反应条件
thionyl chloride in chloroform
参考文献
KANDULA, Mahesh
Patent: WO2013/168000 A1, 2013 ;
Location in patent: Paragraph 0096; 0097 ;
反应条件
sodium hydroxide in water
参考文献
KANDULA, Mahesh
Patent: WO2013/168000 A1, 2013 ;
Location in patent: Paragraph 0098 ;
反应条件
potassium hydroxide; Aliquatreg; 336 T=80°C; 1 h;
参考文献
Galons; Miocque; Combet-Farnoux; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 5108 - 5109
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4094870 A1, 1978 ;
反应条件
potassium hydroxide in tetrahydrofuran; water
1.5 h; Ambient temperature; Yield given;
参考文献
Matsuo; Taniguchi; Ueda
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1141 - 1150
反应条件
hydrogenchloride; sodium hydroxide in water; toluene
参考文献
Mallinckrodt, Inc.
Patent: US4242274 A1, 1980 ;
反应条件
sodium hydroxide in water; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US4048211 A1, 1977 ;
反应条件
sodium hydroxide; dibenzo-18-crown-6
1.) DMSO, water; 2.) 45 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Unterhalt; Coesfeld
Scientia Pharmaceutica, 2000 , vol. 68, # 3 p. 229 - 234