3’,4’-二氟乙酰苯胺合成路线 （共 20 条）
反应条件
nitric acid in acetic acid T=90°C; 4 h;
参考文献
Leyva, Socorro; Castanedo, Victor; Leyva, Elisa
Journal of Fluorine Chemistry, 2003 , vol. 121, # 2 p. 171 - 175
反应条件
1: 82 percent / HNO3, H2SO4 / 1 h / 5 - 10 °C 2: 70 percent / HCl / ethanol / 2 h / Heating 3: 42 percent / SnCl2.2H2O / HCl / 2 h / 50 - 60 °C View Scheme
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
反应条件
1: 82 percent / HNO3, H2SO4 / 1 h / 5 - 10 °C 2: 70 percent / HCl / ethanol / 2 h / Heating 3: 57 percent / sodium metal / 3 h / Heating View Scheme
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
参考文献
Roe et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 28,29
反应条件
1: 24 percent / HNO3 / acetic acid / 4 h / 90 °C 2: 58 percent / CF3CO2H; NaNO2; aq. NaN3 / H2SO4 / 15 °C 3: 40 percent / acetic acid / 6 h / 100 - 110 °C View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
sulfuric acid; nitric acid T=0 - 16°C; 1.5 h;
参考文献
Kotovskaya; Charushin; Chupakhin; Kozhevnikova
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 3 p. 369 - 374
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=70°C; 16 h;
参考文献
US6339091 B1, ;
Example 81 ;
反应条件
acetic anhydride; sodium hydrogencarbonate; triethylamine in dichloromethane; pentane
参考文献
Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;
参考文献
El-Abadelah, Mustafa M.; Nazer, Musa Z.; El-Abadla, Naser S.; Meier, Herbert
Heterocycles, 1995 , vol. 41, # 10 p. 2203 - 2220
反应条件
sodium chloride; acetic anhydride; sodium hydrogencarbonate; triethylamine in dichloromethane; pentane
参考文献
Bigg, Dennis; Lavergne, Olivier; Pla Rodas, Francesc; Pommier, Jacques; Ulibarri, Gerard; Harnett, Jerry; Rolland, Alain; Liberatore, Anne-Marie; Lanco, Christophe; Cazaux, Jean-Bernard; Le Breton, Christine; Manginot, Eric
Patent: US2003/4150 A1, 2003 ;
