1-(3-氟苯基)-2-硫脲合成路线 （共 12 条）
反应条件
sodium hydroxide in water; acetone
参考文献
Tremont, Samuel J.; Koeller, Kevin J.; Neumann, William L.
Patent: US2002/183307 A1, 2002 ;
反应条件
1: With benzoyl chloride in acetone 1 h; Heating; 2: With sodium hydroxide 1.5 h; Heating; Further stages.;
参考文献
Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607
反应条件
1: 75 percent / benzene 2: 60 percent / 2,5 N NaOH / 100 °C View Scheme
参考文献
Bayer Aktiengesellschaft
Patent: US5356864 A1, 1994 ;
反应条件
1: Ammonium thiocyanate With benzoyl chloride in acetone Reflux; 2: 3-fluorophenylamine Reflux; 3: With sodium hydroxide in water T=80°C;
参考文献
Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797
反应条件
sodium hydroxide T=100°C;
参考文献
Gupta, K. A.; Saxena, Anil K.; Jain, Padam C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 228 - 233
参考文献
Browne; Dyson
Journal of the Chemical Society, 1931 , p. 3285,3299
反应条件
1: 64 percent / bromine / CH2Cl2 / 3 h / Heating 2: 76 percent / aq. potassium hydroxide / 5 h / Heating View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607
反应条件
bromine in dichloromethane 3 h; Heating;
参考文献
Schnur, Rodney C.; Fliri, Anton F. J.; Kajiji, Shama; Pollack, Vincent A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 914 - 918
反应条件
bromine in dichloromethane 3 h; Heating;
参考文献
Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607
反应条件
bromine in dichloromethane; water
参考文献
Tremont, Samuel J.; Koeller, Kevin J.; Neumann, William L.
Patent: US2002/183307 A1, 2002 ;
