(4-三氟甲基联苯-4-基)-甲醇合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
US2009/215843 A1, ;
Page/Page column 30-31 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
WO2013/78430 A1, ;
Paragraph 0353 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.166667 h; 2: With potassium hydrogensulfate; water; ethyl acetate in tetrahydrofuran T=0°C;
参考文献
WO2005/118542 A1, ;
Page/Page column 118-119 ;
WO 2005/118542 A1
反应条件
caesium carbonate; PdCl2[dppf] in tetrahydrofuran; N,N-dimethyl-formamide
反应条件
sodium hydride in methanol T=20°C; 2 h;
参考文献
EP1216225 B1, ;
Page/Page column 43 ;
反应条件
1: palladium diacetate; sodium carbonate / ethylene glycol dimethyl ether; water / 3 h / |Inert atmosphere; |Reflux 2: sodium tetrahydroborate; ethanol / 1 h / 20 °C / |Cooling with ice View Scheme
反应条件
1: palladium diacetate; sodium carbonate / ethylene glycol dimethyl ether; water / 3 h / |Inert atmosphere; |Reflux 2: sodium tetrahydroborate; ethanol / 1 h / 20 °C / |Cooling with ice View Scheme
反应条件
thionyl chloride in chloroform
T=20°C;
参考文献
Bartel, Stephan; Hahn, Michael; Moradi, Wahed Ahmed; Becker, Eva-Maria; Roelle, Thomas; Stasch, Johannes-Peter; Schlemmer, Karl-Heinz; Wunder, Frank; Knorr, Andreas
Patent: US2009/291993 A1, 2009 ;
Location in patent: Page/Page column 24 ;
