3-环己基-1,1,1-三氟丙酮合成路线 （共 8 条）
反应条件
hydrogenchloride; ethanol; platinum T=140°C; P=73550.8 - 88260.9 Torr; Hydrogenation;
参考文献
Nes; Burger
Journal of the American Chemical Society, 1950 , vol. 72, p. 5409,5412
反应条件
hydrogen fluoride in dichloromethane 2 h; Ambient temperature;
参考文献
Begue, J. P.; Mesureur, D.
Journal of Fluorine Chemistry, 1988 , vol. 39, p. 271 - 282
反应条件
1: 46 percent / benzene / Heating 2: 95 percent / 40percent aq. HF / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Begue, J. P.; Mesureur, D.
Journal of Fluorine Chemistry, 1988 , vol. 39, p. 271 - 282
反应条件
1: NaNH2, hexamethyldisilazane / benzene / Heating 2: 46 percent / benzene / Heating 3: 95 percent / 40percent aq. HF / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Begue, J. P.; Mesureur, D.
Journal of Fluorine Chemistry, 1988 , vol. 39, p. 271 - 282
反应条件
1.1: pyridine / dichloromethane / 0 - 20 °C 2.1: cesium fluoride / toluene / 0.17 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran; hexane / 2 h / 50 °C View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran; hexane / 2 h / 50 °C View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube 1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube 1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube 2.1: oxoammonium salt; DBN / dichloromethane / 4 h / 20 °C / |Sealed tube View Scheme
参考文献
Kelly, Christopher B.; Mercadante, Michael A.; Hamlin, Trevor A.; Fletcher, Madison H.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8131 - 8141
反应条件
ethanol; ammonia; nickel
T=135 - 140°C; P=125036 Torr; Hydrogenation;
参考文献
Nes; Burger
Journal of the American Chemical Society, 1950 , vol. 72, p. 5409,5412
