3-beta-羟基-12-氧代-5-beta-胆烷酸合成路线 （共 15 条）
反应条件
1: thionyl chloride / 1 h / 0 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 20 °C 3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
反应条件
1: thionyl chloride / 1 h / 0 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 20 °C 3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 20 °C / Inert atmosphere 4: water; lithium hydroxide hydrate / tetrahydrofuran / 20 °C View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
反应条件
methanol; sodium hydroxide
T=20°C; 2 h;
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
Location in patent: Page/Page column 48 ;
反应条件
1: chromium(VI) oxide; acetic acid / 60 °C
2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 2585.81 Torr
3: sodium hydroxide; methanol / 2 h / 20 °C
View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
反应条件
1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 2585.81 Torr
2: sodium hydroxide; methanol / 2 h / 20 °C
View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
反应条件
hydrogen bromide; acetic acid; platinum
Hydrogenation;
参考文献
Berliner; Schoenheimer
Journal of Biological Chemistry, 1938 , vol. 124, p. 525,535
Full Text Show Details
Kyogoku
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1937 , vol. 246, p. 99,103
反应条件
1: acetic acid
2: diethyl ether; methanol
3: Raney nickel; methanol / Hydrogenation
4: methanol. KOH-solution
View Scheme
参考文献
Sawlewicz; Reichstein
Helvetica Chimica Acta, 1937 , vol. 20, p. 992,995
参考文献
Sawlewicz; Reichstein
Helvetica Chimica Acta, 1937 , vol. 20, p. 992,995
反应条件
1: diethyl ether; methanol
2: Raney nickel; methanol / Hydrogenation
3: methanol. KOH-solution
View Scheme
参考文献
Sawlewicz; Reichstein
Helvetica Chimica Acta, 1937 , vol. 20, p. 992,995
反应条件
1: Raney nickel; methanol / Hydrogenation
2: methanol. KOH-solution
View Scheme
参考文献
Sawlewicz; Reichstein
Helvetica Chimica Acta, 1937 , vol. 20, p. 992,995
