1-(2-氨乙基)-4-苄基哌嗪合成路线 （共 6 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 3 h; Heating / reflux; 2: With water in tetrahydrofuran 15 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1695961 A1, 2006 ;
Location in patent: Page/Page column 99-100 ;
反应条件
hydrazine hydrate in ethanol T=20 - 80°C; 18 h;
参考文献
GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca
Patent: WO2011/150183 A1, 2011 ;
Location in patent: Page/Page column 155; 157-158 ;
WO 2011/150183 A1
反应条件
hydrogen bromide in acetic acid 1 h; Ambient temperature;
参考文献
Nakao, Kazuya; Shimizu, Ryo; Kubota, Hitoshi; Yasuhara, Mikiko; Hashimura, Yoshimasa; Suzuki, Toshikazu; Fujita, Toshio; Ohmizu, Hiroshi
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 849 - 868
反应条件
1: 96 percent / K2CO3 / Heating 2: 75 percent / LiAlH4 / tetrahydrofuran / 20 °C View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
triethylamine in tetrahydrofuran T=0°C; 5 h; Yield given;
参考文献
Saxena; Agarwal; Patnaik
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2970 - 2976
反应条件
1: dichloromethane / 1 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 15 h / 20 °C / Autoclave View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/294775 A1, 2011 ;
