4-(1-氨基乙基)-1-哌啶羧酸 1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
1: With ammonium acetate in methanol
T=20°C; 1.5 h;
2: With sodium cyanoborohydride in methanol
T=20°C;
3: With sodium hydroxide; water in methanol
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 70 ;
WO 2008/079346 A1
反应条件
ammonia; hydrogen in ethanol; chloroform
参考文献
Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.
Patent: US2002/165241 A1, 2002 ;
反应条件
1: 1-(4-piperidinyl)ethanone With methanol; palladium 10 on activated carbon; water; ammonium formate
T=20°C; 16 h;
2: di-tert-butyl dicarbonate With triethylamine in dichloromethane
T=20°C; 0.25 h;
参考文献
Budzik, Brian; Garzya, Vincenzo; Shi, Dongchuan; Foley, James J.; Rivero, Ralph A.; Langmead, Christopher J.; Watson, Jeannette; Wu, Zining; Forbes, Ian T.; Jin, Jian
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3540 - 3544
