1,4-双(2-溴乙基)苯合成路线 （共 7 条）
反应条件
acetone; sodium iodide
参考文献
Ruggli; Theilheimer
Helvetica Chimica Acta, 1941 , vol. 24, p. 899,910
反应条件
1: 38 percent / NaBH4 / ethanol; tetrahydrofuran / 13 h / 40 - 50 °C 2: 6 percent / 0.05 h / 650 °C View Scheme
参考文献
Higuchi, Hiroyuki; Tani, Keita; Otsubo, Tetsuo; Sakata, Yoshiteru; Misumi, Soichi
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 11 p. 4027 - 4036
反应条件
dibromotriphenyl-phosphorane in dichloromethane
T=20°C; 18 h;
参考文献
Theravance, Inc.
Patent: US2005/203167 A1, 2005 ;
Location in patent: Page/Page column 23 ;
US 20050203167 A1
反应条件
1: sulfuric acid / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran
3: carbon tetrabromide; triphenylphosphine
View Scheme
参考文献
The Penn State Research Foundation
Patent: US8003633 B1, 2011 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran
2: carbon tetrabromide; triphenylphosphine
View Scheme
参考文献
The Penn State Research Foundation
Patent: US8003633 B1, 2011 ;
反应条件
1: sodium; butanol-(1)
2: glacial acetic acid; HBr / 100 °C
View Scheme
参考文献
Ruggli; Theilheimer
Helvetica Chimica Acta, 1941 , vol. 24, p. 899,910
反应条件
bromine; iodine; iron in dichloromethane
114 h; Ambient temperature;
参考文献
Bradsher, Charles K.; Hunt, David A.
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4608 - 4610
