1-(3-三氟甲基苯基)乙醇合成路线 （共 40 条）
反应条件
1: 14.5 g / conc. HCl / 2 h / Heating 2: Et3N; HCO2H / RuCl(p-CH3C6H4-i-C3H7)(TsNHCHPhCHPhNH2) / dimethylformamide / 27 h / 50 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 2 p. 432 - 437
反应条件
1.1: NaNO2; aq. HCl / 0.33 h / -5 - 0 °C 1.2: CuSO4; AcONa*3H2O / aq. HCl / 1.5 h / 0 - 15 °C 2.1: 14.5 g / conc. HCl / 2 h / Heating 3.1: Et3N; HCO2H / RuCl(p-CH3C6H4-i-C3H7)(TsNHCHPhCHPhNH2) / dimethylformamide / 27 h / 50 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 2 p. 432 - 437
反应条件
1: With (-)-(R,R)-TADDOL; aluminum isopropoxide in diphenylether T=90°C; 1 h; 2: α-methyl-3-trifluoromethylbenzyl alcohol in diphenylether T=90°C; 0.166667 h; Product distribution / selectivity;
参考文献
US2009/30235 A1, ;
Page/Page column 12 ;
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 40 h;
参考文献
Tetrahedron Asymmetry, , vol. 16, # 9 p. 1603 - 1610
反应条件
Candida antartica lipase B in various solvent(s) T=40°C; P=67505.4 Torr; 2 h;
参考文献
Chemistry Letters, , vol. 34, # 8 p. 1102 - 1103
反应条件
p-nitrobenzyl esterase from Bacillus subtilis in aq. phosphate buffer; ethanol 7 h; Enzymatic reaction;
参考文献
RSC Advances, , vol. 3, # 43 p. 20446 - 20449
反应条件
lithium aluminium tetrahydride in diethyl ether Heating;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 9 p. 2385 - 2394
反应条件
bis(norbornadiene)rhodium(I) tetrafluoroborate; C67H63N2O7P; C67H63N2O7P; diethylzinc; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in tetrahydrofuran T=0 - 20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Chemical Communications, , vol. 48, # 2 p. 263 - 265
反应条件
1: diisopropyl ether / 4 h / 30 °C / lipase QL 2: LiAlH4 / diethyl ether / 6 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 11 p. 3285 - 3294
反应条件
M. esculenta enzyme preparation immobilized on alginate gel in diethyl ether T=45°C; 116 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 12 p. 1418 - 1423
