1-(3-三氟甲基苯基)乙醇合成路线 （共 40 条）
反应条件
potassium tert-butylate; hydrogen; RuCl2[(S)-XylHexaPHEMP][(S)-1,1-dianisyl-2-iPr-1,2-Et(NH2)2] in isopropyl alcohol; tert-butyl alcohol T=20°C; P=6205.94 Torr; 0.683333 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 300 - 307
反应条件
borane; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol in tetrahydrofuran Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 112, # 15 p. 5741 - 5747
反应条件
1: trimethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=0°C; 2: α,α,α-trifluoro-m-tolualdehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
反应条件
potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; Tamao oxidation; 16 h;
参考文献
Journal of the American Chemical Society, , vol. 124, # 17 p. 4558 - 4559
反应条件
1.1: (SA,RC,RC)-BINOL=P-N-(1-ethylphenyl)2; allylpalladium chloride dimer / 0.33 h / 20 °C 1.2: 88 percent / trichlorosilane / 60 h / 40 °C 2.1: KF; KHCO3; aq. H2O2 / methanol; tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 17 p. 4558 - 4559
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 8 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
palladium diacetate; oxygen; (-)-sparteine in 1,2-dichloro-ethane T=60°C;
参考文献
Journal of the American Chemical Society, , vol. 123, # 30 p. 7475 - 7476
反应条件
1: With (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl; [Rh(COD)2](1+)*BF4(1-) in ethylene glycol dimethyl ether T=-78 - 20°C; 2: With sodium hydroxide; dihydrogen peroxide in ethylene glycol dimethyl ether T=0 - 20°C; 2 h; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 7 p. 827 - 831
