1: trimethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=0°C; 2: α,α,α-trifluoro-m-tolualdehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
1: 73 percent / 50percent aq. NaOH / 72 h / Ambient temperature 2: EtONa / ethanol / 6 h / Heating 3: 2 N NaOH / 2 h / Heating 4: 5 N H2SO4 / 4.5 h / Heating View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
