N-甲基-N-叔丁氧羰基-D-苯丙氨酸合成路线 （共 19 条）
反应条件
sodium hydroxide; sodium hydrogencarbonate in 1,4-dioxane; water T=20°C;
参考文献
Caplar, Vesna; Zinic, Mladen; Pozzo, Jean-Luc; Fages, Frederic; Mieden-Gundert, Gudrun; Voegtle, Fritz
European Journal of Organic Chemistry, 2004 , # 19 p. 4048 - 4059
反应条件
triethylamine in methanol T=20°C; 0.5 h;
参考文献
Hioki, Kazuhito; Kinugasa, Mizuho; Kishimoto, Michiko; Fujiwara, Miho; Tani, Shohei; Kunishima, Munetaka
Synthesis, 2006 , # 12 p. 1931 - 1933
反应条件
triethylamine in 1,4-dioxane; water 0.166667 h; Ambient temperature;
参考文献
Kim, Sunggak; Chang, Heung
Journal of the Chemical Society, Chemical Communications, 1983 , # 22 p. 1357 - 1358
反应条件
1: With 2,2,2-trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane in tetrachloromethane T=-20°C; 48 h; Inert atmosphere; 2: With hydrogenchloride; water in tetrachloromethane Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Ishihara, Kazuaki; Kosugi, Yuji; Umemura, Shuhei; Sakakura, Akira
Organic Letters, 2008 , vol. 10, # 15 p. 3191 - 3194
反应条件
sodium hydroxide; tert-butyl alcohol
参考文献
Anderson; McGregor
Journal of the American Chemical Society, 1957 , vol. 79, p. 6180,6181
反应条件
sodium hydrogencarbonate
参考文献
Dapperheld, Steffen; Steckhan, Eberhard
Angewandte Chemie, 1982 , vol. 94, # 10 p. 785
反应条件
lithium diisopropyl amide 1) THF, 0 deg C, 10 min, 2) 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
De Nicola; Einhorn; Luche
Tetrahedron Letters, 1992 , vol. 33, # 43 p. 6461 - 6464
反应条件
hydrogen; rhodium in tetrahydrofuran
参考文献
G. D. Searle and Co.
Patent: US4495178 A1, 1985 ;
Title/Abstract Full Text Show Details
G. D. Searle and Co.
Patent: US4603121 A1, 1986 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane; acetonitrile / 18 h / 20 °C / Inert atmosphere 2: dichloromethane / 0.5 h / 20 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 35 °C / Inert atmosphere 4: diethylamine / methanol / 0.75 h / 120 °C / Microwave irradiation View Scheme
参考文献
Zhuo, Chen; Xian, Dong; Hui, Xie; Mei, Li
Heterocycles, 2011 , vol. 83, # 5 p. 1121 - 1127
反应条件
Yield given. Multistep reaction;
参考文献
Barton, Derek H. R.; Herve, Yolande; Potier, Pierre; Thierry, Josiane
Journal of the Chemical Society, Chemical Communications, 1984 , # 19 p. 1298 - 1299
