2,2,2-三氟-1-(3-硝基苯基)-乙醇合成路线 （共 5 条）
反应条件
2,6-dimethylpyridine; oxoammonium salt in dichloromethane T=20°C; Sealed tube;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
2: With water in N,N-dimethyl-formamide
4 h; Acidic conditions;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
BF3 monohydrate complex in water
T=75°C; Friedel Crafts hydroxyalkylation; 48 h; regioselective reaction;
参考文献
Prakash, G. K. Surya; Paknia, Farzaneh; Mathew, Thomas; Mloston, Gzregorz; Joschek, Jens P.; Olah, George A.
Organic Letters, 2011 , vol. 13, # 15 p. 4128 - 4131
反应条件
sodium tetrahydroborate in isopropyl alcohol
1 h; Ambient temperature;
参考文献
Stewart, Ross; Teo, K. C.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 2491 - 2496
反应条件
1: potassium fluoride; triphenyltin fluoride; n-Bu3MeN(+)HSO4(-) / CH2Cl2 / 1 h / 20 °C
2: HCl / H2O / 0.25 h
View Scheme
参考文献
Borkin; Loska; Makosza
Polish Journal of Chemistry, 2005 , vol. 79, # 7 p. 1187 - 1191
