2-氟-5-甲基磺酰硝基苯合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid T=20°C; 2 h;
参考文献
WO2008/84300 A1, ;
Page/Page column 90 ;
WO 2008/084300 A1
反应条件
potassium fluoride T=180°C;
参考文献
Chimija chim. Technol.Chem.Abstr., (NDVS) 1958 122 , p. 3110
反应条件
1: aq. NaOH solution; dimethyl sulfate 2: aqueous hydrogen peroxide; acetic acid 3: sulfuric acid; nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 86, p. 172,180
反应条件
1: aqueous hydrogen peroxide; acetic acid 2: sulfuric acid; nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 86, p. 172,180
反应条件
1: zinc-powder; aqueous sulfuric acid 2: aq. NaOH solution; dimethyl sulfate 3: aqueous hydrogen peroxide; acetic acid 4: sulfuric acid; nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 86, p. 172,180
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=11400.8 Torr; 2 h; Product distribution / selectivity;
参考文献
WO2010/92043 A1, ;
Page/Page column 84 ;
参考文献
Scoffone et al.
Bulletin de la Societe Chimique de France, 1959 , p. 1553,1554
反应条件
ammonium hydroxide in methanol; water T=130°C; 6 h;
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2009/129625 A1, 2009 ;
Location in patent: Page/Page column 33 ;
WO 2009/129625 A1
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20 - 70°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/84300 A1, 2008 ;
Location in patent: Page/Page column 90; 91 ;
WO 2008/084300 A1
参考文献
Scoffone et al.
Bulletin de la Societe Chimique de France, 1959 , p. 1553,1554
