1: methyl 2-fluoroacetate With oxalic acid dimethyl ester; sodium methylate in methanol; pentane T=20 - 25°C; Claisen Condensation; 24.25 h; 2: formaldehyd in pentane T=5 - 10°C; 5 h; ConcentrationReagent/catalystTemperatureTime;
参考文献
DSM IP ASSETS B.V.; DSM FINE CHEMICALS AUSTRIA NFG. GMBH and CO KG; KAPITAN, Peter; SAJTOS, Alexander
Patent: WO2014/1365 A1, 2014 ;
Location in patent: Page/Page column 7-8 ;
