4-(4-甲氧基苯基)丁酸合成路线 （共 52 条）
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon in tetrahydrofuran P=3000.3 Torr; 9 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1726587 A1, 2006 ;
Location in patent: Page/Page column 33 ;
反应条件
barium dihydroxide in methanol T=20°C; 2 h;
参考文献
Anderson, Marc O.; Moser, Jamie; Sherrill, John; Guy, R. Kiplin
Synlett, 2004 , # 13 p. 2391 - 2393
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C; P=760.208 Torr; 3 h;
参考文献
Vercouillie, Johnny; Abarbri, Mohamed; Parrain, Jean-Luc; Duchene, Alain; Thibonnet, Jerome
Synthetic Communications, 2004 , vol. 34, # 20 p. 3751 - 3762
反应条件
1: With [Cu(N,N′-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene)Cl]; lithium methanolate in tetrahydrofuran T=70°C; P=760.051 Torr; 24 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere;
参考文献
Ohishi, Takeshi; Zhang, Liang; Nishiura, Masayoshi; Hou, Zhaomin
Angewandte Chemie - International Edition, 2011 , vol. 50, # 35 p. 8114 - 8117
反应条件
1: 72 percent / AlCl3 / nitrobenzene / Ambient temperature 2: 87 percent / Zn, conc. HCl, HgCl2 / H2O; toluene / 24 h / Heating View Scheme
参考文献
Autrey,R.L.; Scullard,P.W.
Journal of the American Chemical Society, 1968 , vol. 90, p. 4924 - 4929
反应条件
laccase; (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride in water T=20°C; 5 h; Air; optical yield given as percent eeenantioselective reaction;
参考文献
Akagawa, Kengo; Kudo, Kazuaki
Organic Letters, 2011 , vol. 13, # 13 p. 3498 - 3501
反应条件
1: With sodium hydroxide in ethanol 2: With hydrogenchloride in water
参考文献
Mimori, Seisuke; Okuma, Yasunobu; Kaneko, Masayuki; Kawada, Koichi; Nomura, Yasuyuki; Murakami, Yasuoki; Hamana, Hiroshi
Chemistry Letters, 2013 , vol. 42, # 9 p. 1051 - 1052
反应条件
1: 1-methoxy-4-(2-propenyl)-benzene With titanium(IV) isopropylate; cyclopentyl-magnesium chloride in diethyl ether T=-70 - -30°C; 0.0833333 h; 2: carbon dioxide in diethyl ether T=-70 - -30°C; 0.5 h;
参考文献
Six, Yvan
European Journal of Organic Chemistry, 2003 , # 7 p. 1157 - 1171
反应条件
1: H2 / Pd-C / dioxane 2: KOH / ethanol / Heating View Scheme
参考文献
Scarpati,R. et al.
Gazzetta Chimica Italiana, 1967 , vol. 97, p. 654 - 664
反应条件
1: HBr; diacetyl peroxide; diethyl ether 2: magnesium; diethyl ether / anschliessend mit CO2 behandeln View Scheme
参考文献
Ohishi, Takeshi; Zhang, Liang; Nishiura, Masayoshi; Hou, Zhaomin
Angewandte Chemie - International Edition, 2011 , vol. 50, # 35 p. 8114 - 8117
