N-BOC-D-氨基丁酸合成路线 （共 19 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 3 h;
参考文献
Ley, Steven V.; Priour, Alain
European Journal of Organic Chemistry, 2002 , # 23 p. 3995 - 4004
反应条件
sodium hydroxide in methanol; water Heatingother reagent, solvent; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; triethylamine in water; acetone 4 h; Ambient temperature;
参考文献
Cushman, Mark; Jurayj, Jurjus; Moyer, James D.
Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3186 - 3194
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US5206235 A1, 1993 ;
反应条件
1: Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 13.0 g / Et3N / CH2Cl2 / 1 h / 0 °C 3: LDA, LiCl / tetrahydrofuran / 1 h / 0 °C 4: 95 percent / NaOH / H2O; methanol / Heating; other reagent, solvent View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
1: 13.0 g / Et3N / CH2Cl2 / 1 h / 0 °C 2: LDA, LiCl / tetrahydrofuran / 1 h / 0 °C 3: 95 percent / NaOH / H2O; methanol / Heating; other reagent, solvent View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
1: LDA, LiCl / tetrahydrofuran / 1 h / 0 °C 2: 95 percent / NaOH / H2O; methanol / Heating; other reagent, solvent View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
参考文献
PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; WILD, Carl; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; KIMBER, Marc; MAGARACI, Filippo; JOHNSTON, David
Patent: WO2008/134035 A1, 2008 ;
Location in patent: Page/Page column 173-174; 178 ;
反应条件
sodium hydroxide in 1,4-dioxane 8 h; Ambient temperature;
参考文献
Kubik, Aleksandra; Siemion, Ignacy Z.; Stachowiak, Wladyslaw; Szewczuk, Apolinary; Klis, Wieslaw
Polish Journal of Chemistry, 1980 , vol. 54, # 3 p. 435 - 441
反应条件
sodium hydroxide; sodium hydrogencarbonate 1.) reflux, 2.) 1.5 h; Yield given. Multistep reaction;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
