3-氨基-5,6-二苯基-1,2,4-三嗪合成路线 （共 14 条）
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=150°C; Suzuki Coupling; 2.25 h; Inert atmosphere;
参考文献
Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903
反应条件
phosphonic acid dimethyl ester in benzene Decomposition; 10 h; Heating;
参考文献
El-Khoshnieh, Yehia O.
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / -25 °C 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere View Scheme
参考文献
Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903
反应条件
hydrogenchloride hydrolysis; 3 h; Heating;
参考文献
El-Khoshnieh, Yehia O.
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / -20 - -15 °C 2: iron nitrate (III); ammonia / tetrahydrofuran / -33 °C 3: N-bromosuccinmide / N,N-dimethyl-formamide / -25 °C 4: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
反应条件
1: iron nitrate (III); ammonia / tetrahydrofuran / -33 °C 2: N-bromosuccinmide / N,N-dimethyl-formamide / -25 °C 3: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
反应条件
KNH2 in ammonia T=-33°C; 1 h; 15N labelled ammonia, other substituents in 3 position in 5,6-diphenyl-1,2,4-triazines; Mechanism;
参考文献
El-Khoshnieh, Yehia O.
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172
反应条件
ethanol; nitric acid
参考文献
Thiele; Bihan
Justus Liebigs Annalen der Chemie, 1898 , vol. 302, p. 307
反应条件
hydrogenchloride; sodium nitrite 1) CHCl3, 0 deg C, 1.5 h, 2) r.t., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gonsalves, Antonio M. d'A. Rocha; Melo, Teresa M. V. D. Pinho e
Tetrahedron, 1992 , vol. 48, # 33 p. 6821 - 6826
反应条件
tetrahydrofuran; oxygen; nitrogen(II) oxide
4 h; Ambient temperature;
参考文献
Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Ohsawa, Akio
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1547 - 1549
