triethylamine in dichloromethane T=0°C; 3 h;

aluminium trichloride in dichloromethane T=25°C; Friedel-Craft reaction;

((t-Bu)2POH)2PdCl2 in 1-methyl-pyrrolidin-2-one T=25°C; 0.5 h;

暂无反应条件数据

1: Et3N / CH2Cl2 / 48 h / 20 °C 2: 1.72 g / NaOMe / methanol / 72 h / Heating View Scheme

1: 91 percent / pyridine / CH2Cl2 / 1 h / Ambient temperature 2: 82 percent / dimethylsulfoxide / 1 h / Ambient temperature 3: 70.5 percent / zinc, acetic acid / dimethylformamide / 0.75 h / 0 °C 4: thionyl chloride / dimethylformamide / 4 h / 40 - 45 °C 5: 79 percent / pyridine / diethyl ether / 30 h / Heating 6: 1.) sodium hydride, 2.) 1,2-bis(diphenylphosphino)ethane / 2.) tetrakis(triphenylphosphine)palladium(0) / 1,) THF, 0 deg C, 30 min; room temperature, 15 min, 2.) reflux 7: 86 percent / tetramethylammonium acetate / hexamethylphosphoric acid triamide / 3 h / 95 - 100 °C 8: 94 percent / disodium hydrogen phosphate, 6percent sodium amalgam / ethanol; tetrahydrofuran / 0.75 h / -20 °C View Scheme

pyridine in dichloromethane

1: aq. NaOH / tetrahydrofuran 2: potassium tert-butoxide 3: phosphorus pentachloride / CHCl3 / Heating View Scheme

暂无反应条件数据