2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯合成路线 （共 59 条）
反应条件
sulfur; diethylamine in water Gewald reaction; 0.0833333 h; Sonication;
参考文献
Mojtahedi, Mohammad M.; Abaee, M. Saeed; Mahmoodi, Peyman; Adib, Mehdi
Synthetic Communications, 2010 , vol. 40, # 14 p. 2067 - 2074
反应条件
diethylamine in ethanol 0.666667 h; Ambient temperature;
参考文献
Peet, Norton P.; Sunder, Shyam; Barbuch, Robert J.; Vinogradoff, Anna P.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 129 - 134
反应条件
sulfur in ethanol T=50 - 55°C; 2 h;
参考文献
Peet, Norton P.; Sunder, Shyam; Barbuch, Robert J.; Vinogradoff, Anna P.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 129 - 134
反应条件
1: ethylenediammonium diacetate / 0.25 h / microwave irradiation 2: EtONa / ethanol / 0.08 h / microwave irradiation View Scheme
参考文献
AbdelFattah, Bothiana A.; Khalifa, Maha M.A.; El-Sehrawi, Hend; Fayed, Eman; Bayoumi, Ashraf; Said, Makarem
Letters in Drug Design and Discovery, 2011 , vol. 8, # 4 p. 330 - 338
反应条件
1: 42 percent / 0.05 h / Heating 2: conc. NH3 View Scheme
参考文献
Pech; Schleiermachr; Bohm
Pharmazie, 1989 , vol. 44, # 12 p. 860 - 861
反应条件
1: 92 percent / 1.5 h / Heating 2: 48 percent / POCl3 / 15 h / Heating View Scheme
参考文献
Nirogi, Ramakrishna V.S.; Kambhampati, Sastri Rama; Kothmirkar, Prabhakar; Arepalli, Sobhanadri; Pamuleti, Narasimha Reddy G.; Shinde, Anil K.; Dubey
Synthetic Communications, 2011 , vol. 41, # 19 p. 2835 - 2851
反应条件
trichlorophosphate Vilsmeier-Haack Formylation; Cooling with iceMicrowave irradiation;
参考文献
Jain, Kishor S.; Khedkar, Vijay M.; Arya, Nikhilesh; Rane, Prasad V.; Chaskar, Pratip K.; Coutinho, Evans C.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 166 - 175
反应条件
in acetic acid T=20°C; 2 h;
参考文献
Assy, Mohamed G.; Sherif, Mohamed H.; Amr, Abd El-Galil E.; Abdelsalam, Osama I.; Al-Omar, Mohamed A.; Abdalla, Mohamed M.; Ragab, Islam
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 4 p. 766 - 773
反应条件
toluene-4-sulfonic acid; potassium iodide; sodium nitrite in water; acetonitrile T=20°C; 0.0833333 h;
参考文献
Nakhi, Ali; Adepu, Raju; Rambabu; Kishore, Ravada; Vanaja; Kalle, Arunasree M.; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4418 - 4427
反应条件
1: With hydrogenchloride; sodium nitrite in 1,4-dioxane T=-5°C; 0.25 h; 2: With phosphoric acid in diethyl ether T=0°C; 0.5 h;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
