6,11-二氢二苯并[b,e]氧杂卓-11-酮合成路线 （共 9 条）
反应条件
boron trifluoride diethyl etherate; trifluoroacetic anhydride in dichloromethane T=20°C; 1 h;
参考文献
Taljaard, Benjamin; Barton, Benita; McCleland, Cedric W.
South African Journal of Chemistry, 2004 , vol. 57, p. 44 - 48
反应条件
2: P2O5 / ethanol View Scheme
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
2: P2O5 / ethanol View Scheme
参考文献
Jalander, Lars; Oksanen, Lasse; Taehtinen, Johanna
Synthetic Communications, 1989 , vol. 19, # 19 p. 3349 - 3352
反应条件
1: 1 h / 200 °C 2: 79 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Taljaard, Benjamin; Barton, Benita; McCleland, Cedric W.
South African Journal of Chemistry, 2004 , vol. 57, p. 44 - 48
反应条件
1.1: NaH / dimethylformamide 1.2: 70.8 percent / dimethylformamide; benzene / 24 h / Heating 2.1: 80.7 percent / trifluoroacetic anhydride; boron trifluoride etherate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Taljaard, Benjamin; Barton, Benita; McCleland, Cedric W.
South African Journal of Chemistry, 2004 , vol. 57, p. 44 - 48
反应条件
dihydrogen peroxide 1 h; Heating;
参考文献
Misiuk, Wieslawa
Farmaco, 2005 , vol. 60, # 1 p. 61 - 69
反应条件
hydrogenchloride 1.) THF, toluene, 65 deg C, 2 h, 2.) 1 h, 3.) 75 deg C, 1.5 h, ethanol; Multistep reaction;
参考文献
Jalander, Lars; Oksanen, Lasse; Taehtinen, Johanna
Synthetic Communications, 1989 , vol. 19, # 19 p. 3349 - 3352
反应条件
hydrogenchloride; 1,1-dibromo ethane; magnesium 1) THF, reflux; 2) THF, reflux;; Yield given. Multistep reaction;
参考文献
Miodownik, A.; Kreisberger, J.; Nussim, M.; Avnir, D.
Synthetic Communications, 1981 , vol. 11, # 3 p. 241 - 246
反应条件
1: [3-(methylamino)propyl](triphenyl)phosphonium bromide hydrobromide With n-butyllithium in tetrahydrofuran; n-heptane 1.5 h; 2: 6,11-dihydro-dibenz[b,e]oxepin-11-one in tetrahydrofuran; n-heptane 10 h; Heating / reflux; 3: With hydrogenchloride in water pH=2;
参考文献
SOMAXON PHARMACEUTICALS, INC.; PROCOM ONE, INC.
Patent: WO2007/136741 A2, 2007 ;
Location in patent: Page/Page column 18 ;
