1-((2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基)-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲醛合成路线 （共 24 条）
反应条件
sodium tetrahydroborate
参考文献
Terato, Hiroaki; Morita, Hajime; Ohyama, Yoshihiko; Ide, Hiroshi
Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 131 - 141
反应条件
ammonia; water 24 h; Ambient temperature; Product distribution;
参考文献
Nucleosides and Nucleotides, , vol. 15, # 7-8 p. 1287 - 1305
反应条件
triethylamine in methanol; water
T=20°C; 2 h;
参考文献
Ivanov; Simonyan; Belanov; Aleksandrova
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 6 p. 556 - 562
反应条件
pyridine; pyridine hydrogenfluoride in ethyl acetate
T=20°C; 62 h;
参考文献
Schiesser, Stefan; Pfaffeneder, Toni; Sadeghian, Keyarash; Hackner, Benjamin; Steigenberger, Barbara; Schroeder, Arne S.; Steinbacher, Jessica; Kashiwazaki, Gengo; Hoefner, Georg; Wanner, Klaus T.; Ochsenfeld, Christian; Carell, Thomas
Journal of the American Chemical Society, 2013 , vol. 135, # 39 p. 14593 - 14599
反应条件
1: With triethylamine in water
T=60°C; 96 h;
2: With manganese(IV) oxide in methanol
T=50°C; 6 h;
参考文献
Guo, Pu; Xu, Xiaowei; Qiu, Xiaoyu; Zhou, Yimin; Yan, Shengyong; Wang, Changcheng; Lu, Chunjiang; Ma, Wen; Weng, Xiaocheng; Zhang, Xianzheng; Zhou, Xiang
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 10 p. 1610 - 1613
反应条件
acetic acid
T=50°C; 16 h;
参考文献
Ono; Okamoto; Inada; Nara; Matsuda
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 11 p. 2231 - 2237
反应条件
oxygen in phosphate buffer
T=40°C; pH=4.5 - 7.0; 25 h; Further byproducts given;
参考文献
Martini, Michela; Termini, John
Chemical Research in Toxicology, 1997 , vol. 10, # 2 p. 234 - 241
反应条件
oxygen; α,α'-azodiizobutyramidine-dihydrochloride in phosphate buffer
T=40°C; pH=4.5 - 7.0; 25 h; Further byproducts given;
参考文献
Martini, Michela; Termini, John
Chemical Research in Toxicology, 1997 , vol. 10, # 2 p. 234 - 241
反应条件
1: 5 percent Pd(CH3CN)2Cl2 / acetonitrile / 80 °C
2: OsO4, NMO, H2O / acetone; 2-methyl-propan-2-ol
3: TBAF
4: NaIO4, H2O
View Scheme
参考文献
Kittaka, Atsushi; Horii, Chikafumi; Kuze, Tetsuya; Asakura, Takashi; Ito, Katsutoshi; Nakamura, Kazuo T.; Miyasaka, Tadashi; Inoue, Jun-Ichiro
Synlett, 1999 , # SPEC. ISS. p. 869 - 872
反应条件
sodium peroxodisulphate in water
T=75°C; 4 h;
参考文献
Itahara; Yoshitake; Koga; Nishino
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 8 p. 2257 - 2264
