6,11-二氢-5H-二苯并[b,e]氮杂卓合成路线 （共 12 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran Heating / reflux; 2: With water T=20°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/94816 A1, 2005 ;
Location in patent: Page/Page column 70 ;
WO 2005/094816 A1
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
sulfuric acid in dichloromethane T=-40 - 20°C;
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
1: 82 percent / 2 h / Heating 2: 70 percent / polyphosphoric acid; POCl3 / 12 h / 120 °C 3: 91 percent / H2 / 10 percent Pd/C / methanol / 20 °C View Scheme
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
1: 70 percent / polyphosphoric acid; POCl3 / 12 h / 120 °C 2: 91 percent / H2 / 10 percent Pd/C / methanol / 20 °C View Scheme
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
1,4-dioxane; Catalyst M-Chromium oxide; copper(II) oxide T=250°C; P=194910 Torr; Hydrogenation;
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
反应条件
1: 100 percent / ClCH2COOH / propan-2-ol / 16 h / 20 °C 2: 100 percent / NaBH4 / ethanol / 1 h / Heating 3: 85 percent / H2SO4 / CH2Cl2 / -40 - 20 °C View Scheme
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
1: 100 percent / NaBH4 / ethanol / 1 h / Heating 2: 85 percent / H2SO4 / CH2Cl2 / -40 - 20 °C View Scheme
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
1: 100 percent / ClCH2COOH / propan-2-ol / 16 h / 20 °C 2: 100 percent / NaBH4 / ethanol / 1 h / Heating 3: 85 percent / H2SO4 / CH2Cl2 / -40 - 20 °C View Scheme
参考文献
Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
