2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺合成路线 （共 12 条）
反应条件
1.1: SOCl2 / 75 °C 2.1: AlCl3 / 1,2-dichloro-ethane / 20 °C 3.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C 4.1: NaH / tetrahydrofuran / 20 °C 4.2: 60 percent / tetrahydrofuran / 20 °C 5.1: 81 percent / H2; ethanolic NH3 / Raney-nickel / 40 °C / 3600.36 Torr View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
反应条件
1.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 2.1: SOCl2 / 75 °C 3.1: AlCl3 / 1,2-dichloro-ethane / 20 °C 4.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C 5.1: NaH / tetrahydrofuran / 20 °C 5.2: 60 percent / tetrahydrofuran / 20 °C 6.1: 81 percent / H2; ethanolic NH3 / Raney-nickel / 40 °C / 3600.36 Torr View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
