4,6-二氯-2-甲砜基嘧啶合成路线 （共 9 条）
反应条件
in dichloromethane; ethyl acetate
参考文献
Buser-Doepner, Carolyn A.
Patent: US2009/105270 A1, 2009 ;
反应条件
in tetrahydrofuran Inert atmosphere; chemoselective reaction;
参考文献
Synthesis (Germany), , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
反应条件
in water; ethyl acetate; tert-butyl alcohol T=90°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/87245 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087245 A2
Title/Abstract Full Text Show Details
MERCK and CO., INC.; VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/87246 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087246 A2
反应条件
in ethyl acetate T=5 - 20°C; 1.41667 h;
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BLACKLEDGE, Charles, William; BRADY, Gerald, Patrick; FENG, Yanhoug, G.; GRANT, Seth, W.; MEDINA, Jesus, Rahul; MILLER, William, H.; ROMERIL, Stuart, P.
Patent: WO2010/59658 A1, 2010 ;
Location in patent: Page/Page column 189-190 ;
WO 2010/059658 A1
反应条件
sodium methylate T=-78°C;
参考文献
Woods, Keith W.; Lai, Chunqiu; Miyashiro, Julie M.; Tong, Yunsong; Florjancic, Alan S.; Han, Edward K.; Soni, Niru; Shi, Yan; Lasko, Loren; Leverson, Joel D.; Johnson, Eric F.; Shoemaker, Alexander R.; Penning, Thomas D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1940 - 1943
反应条件
sodium hydride in tetrahydrofuran
T=-70 - 0°C; 1.5 h; Inert atmosphere; chemoselective reaction;
参考文献
Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
反应条件
sodium hydride in tetrahydrofuran
T=-70 - 0°C; 1.5 h; Inert atmosphere; chemoselective reaction;
参考文献
Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
反应条件
2,6-dimethylpyridine in dimethyl sulfoxide
T=20°C; 1 h; Inert atmosphere; SolventTimeReagent/catalyst; chemoselective reaction;
参考文献
Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
反应条件
2,6-dimethylpyridine in dimethyl sulfoxide
T=20°C; 0.5 h; Inert atmosphere; chemoselective reaction;
参考文献
Baiazitov, Ramil; Du, Wu; Lee, Chang-Sun; Hwang, Seongwoo; Almstead, Neil G.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0253-OP, p. 1764 - 1784
