5,7-二氯-2,3-二氢茚醇-1-酮合成路线 （共 6 条）
反应条件
chlorosulfonic acid T=0°C; Friedel-Crafts reaction; 1 h;
参考文献
Sharma, Anil K.; Subramani, Amutha V.; Gorman, Christopher B.
Tetrahedron, 2007 , vol. 63, # 2 p. 389 - 395
反应条件
1: 71 percent / triethylammonium formate 2: 100 percent / H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 3: 99 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: H2 / platinum oxide / aq. ethanol 2: oxalyl chloride / CH2Cl2 / 20 °C 3: aluminum chloride / CH2Cl2 / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: 100 percent / H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 2: 99 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme
参考文献
Sharma, Anil K.; Subramani, Amutha V.; Gorman, Christopher B.
Tetrahedron, 2007 , vol. 63, # 2 p. 389 - 395
反应条件
1: concentrated aqueous HCl 2: (i) SOCl2, (ii) AlCl3, CH2Cl2 View Scheme
参考文献
Strehlke; Hoyer; Schroeder
Archiv der Pharmazie, 1975 , vol. 308, # 2 p. 94 - 109
反应条件
(i) SOCl2, (ii) AlCl3, CH2Cl2; Multistep reaction;
参考文献
Strehlke; Hoyer; Schroeder
Archiv der Pharmazie, 1975 , vol. 308, # 2 p. 94 - 109
